When Jim and Steve attend their high school reunion, they find things aren't quite as they remembered. Billy tags along and poses as an able-bodied alumnus.
Steve falls off the wagon and goes on a bender, leaving Jim and Billy to care for Emily during his visitation with her, after discovering his ex-wife is pregnant and plans to remarry.
Billy decides he wants to have a real relationship, so Jim and Steve create a fake online dating profile to help him meet girls. Steve goes to a bar and tests out Jim's pick-up strategies on a co-worker and returns home to find Billy in a compromising position.
Jim stops drinking in solidarity with Steve and starts to suffer from panic attacks. Through a misunderstanding, Jim ends up at a married ex-girlfriend's house for a costume party.
One of Billy's friends with muscular dystrophy dies forcing the realization on the guys that Billy doesn't have much time left. Jim copes by chasing after the dead guy's sister.
In an effort to do something nice for Steve, Jim invites him along to a gig in Omaha -- but once they get on the plane Jim gets embroiled in a battle with another passenger about plane etiqutte and a middle seat.