More than one doctor's life is left hanging in the balance following the boat explosion. Duffy returns to the emergency department as an agency nurse. Louise fights to save a couple's child.
Connie fights to save Charlie's life. Duffy inspires Louise to become a nurse. Gang violence spills through the hospital doors, endangering more lives.
Lily works alongside new junior doctor Alicia Munroe to treat a pregnant patient. Dylan and Lofty's friendship strengthens. Honey decides to leave Holby set up a business elsewhere.
Alicia comes to terms with a traumatic shift. Iain and Rita share a moment together. Cal brings Matilda into the hospital after failing to find childcare.
Dixie helps save HART paramedic Jess after she sustains injuries in the woodlands. Lily turns unpopular as the department learn she bullied Alicia. Cal's world is rocked by a revelation about Matilda.
Iain and Dixie are injured when the ambulance skids on ice. New receptionist Jack Diamond aims to improve Christmas spirits in the emergency department.
Noel is assaulted as he and Big Mac walk home from the park. Iain and Dixie praise Big Mac for saving Noel's life, unaware Big Mac hid in the toilets during the assault.
Connie faces a day from hell when her professional, personal and love life collides. Ethan shuts Cal out in the aftermath of his diagnosis. Noel listens to Big Mac.
Jacob tracks down a dangerous drug dealer. Big Mac steals from the medicine cabinet to aid his addiction. Zoe defends Max when his act of kindness backfires.
Mark plays a vicious trick on Rita to teach her a lesson. Noel supports Big Mac as his addiction spirals out of control. Jack quits his job to work in the travel industry.
Zoe and new consultant Elle fear for their lives as they are held hostage in the pub. Max realises he must let go of his past. David struggles to fit in.
Elle and Connie bitterly clash. Dylan is less than impressed by Brian's return to the hospital. Charlie tries to encourage David to become more confident.
Charlie threatens to tells Rita about Big Mac's struggles in an attempt to help him see sense. Iain leaves Rita heartbroken. Dylan tries to befriend Max.
Elle is on a mission to find out who has been stealing painkillers from the emergency department. Rita runs back into Iain's arms. Ethan attempts to flirt with a patient.
An old face returns to the emergency department. Iain freaks out when Rita tells their colleagues they are in a relationship. Robyn and Glen get closer.
Connie and Jacob work together to save a man stuck in a storm drain. Rita manipulates her accident to get more security from Iain. Max and Dylan strike up an unlikely friendship.