The utter and complete lack of self esteem conveyed by Thurman and Lewis in the lead roles will be testament to their talent as you suffer through the neon-lit pallor of 1980s New Jersey bar life. If you want to be painfully reminded of every person whom you either broke up with or declined to date due to his or her extreme self loathing, lack of direction, or bad taste in juke box selections, then this is your ticket. If not, you're better off spending two hours in your favorite working-class bar, because this film is such a perfect portrayal of unfortunate mediocrity (and achieves just as much intrigue) that you might as well enjoy it in real 3D and in a cloud of real cigarette smoke. If you want a movie that makes self misery compelling, treat yourself to Barfly, in which you'll get all the glory of a Charles Bukowski script fleshed out by some strong acting from Rourke and Dunaway. If you must have a Thurman fix in this genre, try Beautiful Girls, which while not a very good film in its own right certainly beats Hysterical Blindness hands down.
Review of Hysterical Blindness
