Flashback from Beginning of the End (2014) and New Life (2019) featuring Fitz and Simmons are shown as part of Jemma's memories.
The sweatshirt of Leo Fitz in the flashback is identical to the one in the flashback of 2022 in The Last Day (2018).
"Brand New Day" originally aired on ABC on August 5, 2020 and was watched by 1.25 million viewers, a series and season low.
The title shares its name with the Spider-Man comic arc of the same name.