Rick the Hormone Monster's dialogue starts being subtitled in this episode, because viewers complained that they couldn't understand him.
The scene where Andrew's parents wax his upper lip is based on a real event in writer Andrew Goldberg's life where his parents did just that. According to Nick Kroll, Goldberg was unable to grow a full mustache for years after that (which they dubbed 'the reverse Hitler').
Andrew suggests to Nick to use his oversized jersey as a night shirt, a nod to John Mulaney's (Voice of Andrew) most recent stand up special, "Kid Gorgeous at Radio City" (2018)