Karma (voiced by Shaquille O'Neal) says "boiboi", which is an inside joke with talk show host Jimmy Fallon, whom he calls "boiboi".
During the first scene at the dog show the chihuahua Chloe and her mate Papi from the movie Beverly Hills Chihuahua get a short cameo, with Chloe (noticible by the same voice from the movie and same diamond necklace) having a quick line about talking dog movies not being mainstream anymore.
One of the two credited screenwriters, Max Bodkin, claims that the film was heavily rewritten by the other credited writer Marc Hyman and 12 uncredited writers.