On numerous occasions, Dr. Neil Watts makes references to pop culture and anime. One example would be his exclamation of the classic phrase "HADOUKEN" from the "Street Fighter" series of arcade fighting games, while preparing a memory link.
There is a reference to The Matrix (1999). When Neil picks up the phone call from Eva, he answers "Morpheus?". She then replies, "No, you idiot, it's me, Eva."
To the Moon was created using the RPG Maker XP engine, but isn't made like a normal RPG. It contains no battle system (Asides from a joke battle near the beginning), party system or inventory system.