All the disabled characters are played by disabled actors.
The Toulouse-Lautrec high school is a real high school in Vaucresson, in the Paris suburbs, which functions like it does in the series and where it was actually filmed during the school year, with almost all the extras comprised of students, former students and staff. Series creator Fanny Riedberger attended the school as a teen and based the character of Victoire on herself and the plot lines on her own experiences and those of her schoolmates, hoping to change people's understanding of disabilities.