The voices of Sam and Gustav's agents heard over the phone throughout the film are that of Lake Bell.
Although uncredited in the actual film credits, Cameron Diaz is listed in the credits for the movie-within-the-movie "The Amazon Games", which can be seen during the final voice class at the end of the film.
Much like his character in the film, Fred Melamed is an accomplished voice actor in real life. According to Melamed himself, Lake Bell was unaware of this when she first offered him the role of Sam.
The title is a reference to the frequent phrase uttered by the late Don LaFontaine in many film trailers.
There is a flirtation between Cher (played by Tig Notaro), and Nancy (played by Stephanie Allynne). The actresses started dating after the production and are now married with twin sons.