This follows the trend of another movie in the unofficial "Amityville Series" making reference to the real life case of Ronald DeFeo Jr. in title only. As none of the the movies in the "Amityville Series" have anything to do with each other apart from the title (Excluding the remake of the the original) this can be seen as a continuation of the series depending on whether you class them as a series or not.
Lisa Templeton begins a new job as a cleaner at High Hopes Hospital, a mental institution in Amityville, Long Island. Initially delighted to get the job, Lisa soon realises that all is not as it seems.