Leela already said a few episodes prior to this one that she can't take off her wrist device, yet she takes it off with no problem here.
Leela's boots fall through the open Planet Express dome, yet earlier it was shown that Mom had already piloted the Momsanto ship away from that area.
Why would the sink's water pipe from the giant's room lead to the Bridge of Mom's ship? Everytime the giant uses the sink, it would flood the Bridge.
There is no dirt/grass around the Planet Express office, everything is cemented over, and therefore the seed would never had the opportunity to germinate with soil.
The Momsanto ship is rocking back and forth, yet no one is turning the steering wheel which is stationary.
How would Fry and Bender know where to go in a sky that big to find Leela?
Why would Mom do something nice to help others, even if for a profit, when in the past her evil plots have included taking over the universe and using Earth as a giant death weapon and controlling all robots on Earth to kill all humans?