One of Professor Nimnul's test subjects is a Tasmanian devil, whose vocalizations are similar to that of the Looney Tunes character Taz. Jim Cummings, who did the animal vocal effects, went on to become Taz's primary voice actor in the early 1990s.
Dale mentions several classic monsters, including the wolf man (werewolf), Dracula, and the Frankenstein Monster.
The episode title alludes to the phrase, "a wolf in sheep's clothing."