In the original movie, Andromeda was crystalline and composed of only carbon, hydrogen, oxygen, and nitrogen, not sulfur.
In the original movie, the people of Piedmont brought the satellite to the town physician, not the fire chief.
In the original movie, there were only 4 members of the Wildfire team, and the surgeon was the "odd man out" Dr. Mark Hall (actor James Olson). He was the one who made it to the wall panel to stop the bomb.
In the original movie Ramon Bieri played Major Manchek. In this miniseries, Andre Braugher played General Mancheck. Rank and spelling are different.