Pamela Clemm's driver's license lists her home address as "1849 Reynolds Street." Edgar Allan Poe died in 1849. Additionally, the license shows her birthday as January 19th, which is also Poe's birthday.
Pluto is the same name as the cat in Poe's 'The Black Cat'
The woman who is in Dr Ruiz's office with her paperwork is identified as "Pamela Clemm." Poe's wife/cousin's name was Virginia Eliza Clemm Poe."
The videogame that Leo plays in this episode is 'The Last of Us Part II'. The scene is accompanied by the slight sound of one of the 'The Last of Us' soundtrack chimes
Rahul Kohli wears a Nike hoodie with YNWA across the chest - this means You'll Never Walk Alone, the motto of Liverpool FC, his favourite football team.