In 1943 a woman from Acitrezza tells her son a legend about a werewolf, just before he leaves with his father for night fishing. The full moon will make the boy sick, becoming the progenitor of a werewolf family.
To avoid bankruptcy, Franco, a suburban butcher, turns to two brothers who are usurers but is unable to pay off his debts. The constant abuses of the brothers will ignite his thirst for revenge in Franco.
Antonio, a private car driver, finds himself once again taking on the role of driver for a dangerous underworld tour. Antonio and his friend, Renato, forced by a Gangster, drive through the Sicilian hinterland to a very small village.
In 1891, in Sicily, few families controlled most of the territory. In this context, two brothers, Michele and Giovanni, find themselves involved in a settling of scores, that will lead them to undertake a desperate escape to salvation.