While questioning Sam Merlotte, Sheriff Dearborne states that Sam doesn't have a social security number. Without one, Sam couldn't register a business, obtain licenses and permits, or file income taxes.
When Andy mentions having seen supernatural events, no one believes him and everyone calls him crazy but this makes no sense since this story takes place in a world where humans, vampires and other beings coexist together. Characters should be used to seeing supernatural events given everything else happening around them all the time.