Dr. Lisa Bratwurst only needs the last ingredient to make her powerful machine work. With the help of a bionic hot dog and Gene the pack of french fries, she finds what she's been looking for: Quantum Relish.
Gene the package of french fries has a sister named Gebra who wants him to get his old band back together to play for her wedding. Gene decides to take Dan, Rebecca, and their son Brandon on a road trip to help him on his journey.
Gene the package of french fries and Steve the Root Beer have made it to their next stop on the road trip. They find Melba the Pickle floating in a pond.
They've finally made it to Gene's sister's wedding. The two brides, Gebra and Maizie, stand at the altar ready to marry when the Evil Witch Pam and her possessed Racoon show up for their revenge.
In a flashback, Evil Witch Pam meets with a hooded figure she calls "master." Together they plot the demise of the Hot Dog clan and lure them to Hawaii.
Evil Witch Pam reveals that some of those who walk among them are holograms. She pulls the lever to drop everyone into molten lava right after the brides say their vows and the band plays their song.