On the way home from a wine festival in the Kaiserstuhl, radio presenter Beate Schmidbauer, a friend of police chief Cornelia Harms, is knocked unconscious and raped by an unknown perpetrator. Although the man's DNA can be ascertained, Franziska Tobler and Friedemann Berg do not find any equivalent in the databases. Cornelia Harms is close to the case, but given the circumstantial evidence, she can give her friend little hope that the perpetrator will be identified. When, however, the news comes from Alsace that a man with identical DNA has been wanted for years for rape and manslaughter, Franziska and Friedemann rely on a collaboration. Because the French colleagues have an extended DNA feature test. With their knowledge of age, skin and eye color, they could target specific suspects. This is not yet permitted in Germany, but Friedemann Berg and Franziska Tobler use this knowledge to focus on three suspects. Neither of the three is ready to give up DNA samples. At the same time, persistent investigations by the police are not without impact on their lives.