As an adult, the character of Jay looks almost exactly like the actor Jason Mantzoukas who voices the character.
A "Cafeteria Girls" billboard is visible during Nick's car ride.
As Nick and Jessie make their escape in a Mad Max parody Jessie says "That'll do pig" a reference to Babe also directed by Mad Max director George Miller.
The four out-of-order episodes of My Name Is Earl (2005) available on Nick and Jessi's trip to the moon are Dodge's Dad (2009), Jump for Joy (2006), Stole an RV (2008) and Frank's Girl (2007).