Final appearances of eighteen regular or long standing characters prior to the school's move to Merseyside:
- Lee Cornes as Geoff Hankin
- Kelly George as Ray Haynes
- Sally Geoghegan as Jayne Carver Robson
- Clive Willbond Hill as Dai "Hard" Jones
- Oliver Elmidoro as Tom Smith
- Jonathon Marchant-Heatley as Sam "Cracker" Bacon
- Charlotte McDonagh as Lisa West
- Robert Stuart as Matt Singleton
- Michael Obiora as Max Abassi
- Adam Sopp as Darren Clarke
- Daniel Lee as Ben Miller
- Judith Wright as Emily Fraser
- Renee Montemayor as Briony Jones
- Naomi Osei-Mensah as Clare Chaplin
- Emma Willis as Vikki Meades
- Jon Newman as Kieran "Ozzie" Osborne
- Reggie Yates as Carl Fenton
- Nicholas Tizzard as Stephen Deverill.
Incidental music includes "Lifted" by The Lighthouse Family; "Mambo No.5" by Lou Bega; "Dancing In The Moonlight" by Toploader; "What Took You So Long" by Emma Bunton; "Life Is A Rollercoaster" by Ronan Keating; "True" by Spandau Ballet; "Groovejet" by Spiller feat. Sophie Ellis Bextor; "Everlasting Love" by Edison Lighthouse and "Sex Bomb" by Tom Jones.
Sixth of seven fires at GH: fires also occur in S2 Ep.6; S4 Ep.1; S9 Ep.3; S22 Ep.3; S24 Ep.1 & S29 Ep.9
R.Joseph still named as caretaker on sign at school entrance despite making final appearance in S21 Ep.12.