In Catherine's daydream of having co-workers who aren't all white, the imaginary co-worker George, who Catherine talks to in the lunch room, is played by Lance E. Nichols. Nichols later co-starred with Khandi Alexander--playing Alexander's husband--in the HBO Series "Treme" (2010--2013).
The scene where many 'Matthews' surround Beth and Joe (parodying "Aliens") was one of the difficult to film scenes for the entire series.
As the last scene spoofs the ending of the series "St. Elsewhere". "Newsradio" regular Maura Tierney later had a regular role on "ER" which is a series that "St. Elsewhere" is said to have inspired.