The building used for much of the episode is the old Bullocks Wilshire Department Store, located at 3050 Wilshire Boulevard in Los Angeles, California. It is a 230,000-square-foot very special (21,000 m2) Art Deco building. The building opened in September 1929. Angela Lansbury and her mother, Moya MacGill worked there not long after they moved to America. This contributes to the line of dialogue, where Jessica while walking through the foyer says, "this place holds some very personal memories for me too". It was during her time working in this store that Angela was cast as cockney maid Nancy Oliver in Gaslight.
Two cast members from The Disease (1999). Kate Mulgrew (Captain Janeway) and Musetta Vander (Derran Tai).
Tom Bosley who played sheriff Amos in the first few seasons left to star in his own mystery series "Father Dowling Mysteries" as Father Dowling himself
Guest start Kate Mulgrew's last role before she would play the lead role of Captain Kathryn Janeway on the long -running series Star Trek: Voyager (1995). Coincidentally, the previous episode to this, Time to Die (1994), featured guest actor Robert Beltran, who would go on to be the second lead on Voyager, playing first officer Commander Chakotay.
George Clooney is in the episode "No Laughing Murder" season 3 episode 18. He plays a character called Kip Howard