- Dr. Mark Greene: Thank you, Katie.
- Katie: What did I do?
- Dr. Mark Greene: You just became my very last patient.
- Dr. Mark Greene: Mrs. Raskin. It's been a long time.
- Mrs. Raskin: The service isn't what it used to be.
- Dr. Mark Greene: What seems to be the matter?
- Mrs. Raskin: I have this hangnail, and it's very painful.
- Dr. Mark Greene: I have a brain tumor, and it's inoperable.
- Mrs. Raskin: What?
- Dr. Mark Greene: I win.
- [as Dr. Greene leaves the ER for the very last time]
- Nurse Abby Lockhart: Goodnight Dr. Greene
- Dr. Mark Greene: Goodbye.
- Dr. Mark Greene: [When Mark decides not undergo anymore chemotherapy] I'm finished. I've had enough.
- Elizabeth Corday: You can go up now, and I'll drive you home.
- Dr. Mark Greene: Elizabeth.
- Elizabeth Corday: This isn't something that you decide by yourself on the spur of the moment
- Dr. Mark Greene: This might be the last important decision I get to make.
- Elizabeth Corday: You haven't given it time to work, Mark. Please.
- Dr. Mark Greene: I dropped an ET tube today. I couldn't wrap my thumb around it.
- Elizabeth Corday: That doesn't mean the chemo's not working.
- Dr. Mark Greene: It's a game, Elizabeth. I don't wanna play.
- Elizabeth Corday: Look, it's only the second cycle. This treatment could prolong your life.
- Dr. Mark Greene: Maybe. For a couple of months.
- Elizabeth Corday: Well, then give yourself that time. Give it to me and Ella. Give it to Rachel. Who knows what might happen? We see patients here every day who are told that they should have been dead long ago.
- Dr. Mark Greene: I need to be realistic.
- Elizabeth Corday: You mean give up.
- Dr. Mark Greene: It's not giving up. It's making a choice. I'd rather have two good months than twice that chained to meds and needles and IV stands, stuck in a bed sitting next to other clock-watchers, being prodded and small-talked to by doctors and nurses, all of them with that look in their eye like you're already gone. I don't want to end it like that.
- Dr. Mark Greene: [to a drug-addicted woman who gave birth to a premature baby] Congratulations, you're a mother.
- Gregory Pratt: Do I seem like a punk to you?
- Dr. Mark Greene: No.
- Gregory Pratt: Then stop trying to treat me like one.
- Dr. Mark Greene: I'm sure that you think you're ready for anything.
- Gregory Pratt: Wait. Is this the one about the old guy and the young guy? Because, see, I've heard it all before.
- Dr. Mark Greene: There's a door there that goes outside. If you don't like the way I'm doing this, keep walking.
- Kerry Weaver: [to Mark] It might be best if you left critical procedures to the rest of us.
- Dr. Mark Greene: You're pulling me out of the Trauma Room?
- Kerry Weaver: Anybody else I'd send home. I trust you to recognize your own limitations.
- Gregory Pratt: [about Mark] I just can't figure out what's going on with this guy.
- Susan Lewis: A tumor.
- Gregory Pratt: What?
- Susan Lewis: He has a brain tumor. An inoperable GBM that's recurred. That's what's going on with him. That's what the IV's for. He's in his second cycle of chemo.
- Gregory Pratt: And he's still working?