The house that Isabel rents was chosen by director
Nora Ephron because it had belonged to friends of her parents and she visited it many times as a child. By pure coincidence, those friends were Larry Berns and his wife,
Sandra Gould, who played the second, better-known Gladys Kravitz.
Alice Pearce, the first Gladys Kravitz, died after the second season and was replaced with Gould. Ephron claims in the DVD commentary that she didn't realize this until after the movie was made.
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