The actors snorted milk powder in the cocaine scenes.
George Jung's daughter, Kristina, had a bit part as a clerk but her scene was cut.
Rachel Griffiths plays Ermine Jung (George's mother). The actress is five years younger than Johnny Depp (George).
Ray Liotta who plays George's (Johnny Depp) father is only eight years older than Depp.
When George is sharing a cell in prison with Diego, George is seen reading a paperback while reclining on his top bunk. The book is "Hells Angels" written by Hunter S. Thompson, the author whom Depp previously portrayed in the movie Fear and Loathing in Las Vegas (1998).
When George is in the courtroom the first right before he finds out that Barbara's sick, the words that he is reciting to convince the judge that he is innocent are lines from Bob Dylan's song "It Ain't Me Babe" and Woody Guthrie's song "Pretty Boy Floyd".
George's last line, "There are no more white horses or pretty ladies at my door" is a reference to the Emerson, Lake and Palmer song "Lucky Man".
John Leguizamo was offered a role in this film but turned it down because he was already working on Moulin Rouge! (2001)
A lot of Johnny Depp's dialogue was improvised, including the scene where they are trying to find a place to put all their money from selling coke and his line "We're gonna need a bigger boat" (a quote from Jaws (1975)).
Director Ted Demme died less than a year later, while playing basketball. A postmortem toxicology test showed cocaine in his system.
To prepare for the role Johnny Depp interviewed the real George Jung in prison.
The scene at the hotel (where Johnny Depp gets shot in the shoulder) was supposed to be taking place in Miami Beach. It was filmed at a small hotel outside of downtown Los Angeles, where it was raining and about 40°. Shooting had to be delayed briefly because the actor's breath could be seen on film.
Although she was at the premiere, Emma Roberts did not see the movie until about 6 years after its release.
According to the Director's Commentary, the tape that George Jung leaves for his father near the end of the movie is a verbatim transcript of a tape that the real George Jung recorded under similar circumstances.