- When the Virtual Psychiatrist comes up in the police station, he asks Gibson about a turtle in the desert and about his mother, references to Leon's Voigt-Kampff test in Blade Runner (1982).
- One skier near the beginning mentions he has a cloned snake, another reference to Blade Runner (1982).
- As Adam is leaving the pet cloning store at the mall, he tells the clerk "I might be back" which is a play on his famous "I'll be back" line from the Terminator movies.
- The name was changed from "The Sixth Day" to "The 6th Day" to avoid confusion with The Sixth Sense (1999).
- The Sim-Pal slogan is "A Sim-Pal that's fun to be with!", a derivation from "The Hitch-Hiker's Guide to the Galaxy" series by Douglas Adams. There, the corporation that created robots with "Genuine People Personalities" had the slogan "Your plastic pal that's fun to be with!".
- Christopher Lawford, who plays a police officer in the film, is Arnold Schwarzenegger's cousin by marriage.
- When Adam is locked in the room at the police station, the name of the webcaster appears on the screen as Marianne Wibberley. Wibberley co-wrote the movie with her husband Cormac Wibberley.
- The Coliseum-like building that houses the genetic lab and is blown up at the end is actually the Vancouver Public Library.
- The professional football league that Johnny Phoenix plays for, the XFL, was created in 2000 by WWE Owner Vince McMahon. It only lasted one season.
- Actor Trademark: [Arnold Schwarzenegger] I might be back.
- According to Arnold Schwarzenegger in the DVD featurette 'The Future is Coming', this movie is set in the year 2015.
- Kevin Costner turned down the lead role in this film due to scheduling conflicts with another film.
- The incendiary powder Adam makes is never named specifically, but based on its properties and ingredients, it appears to be thermite. The fact that Adam subsequently conceals thermite in a Thermos may be an in-joke from the filmmakers.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: The henchman Wiley who is killed repeatedly in accidents appears to spoof Wile E. Coyote from the Merrie Melodies and Looney Tunes cartoons. Also, one of the sports teams Drucker owns is called the Roadrunners.
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