In Shayne Hawke's promo before his match with Player Uno, he says that he hates video games and was ostracized as a kid for not playing "Mortal Kombat 3."
Three of the characters, named Cyrax, Sektor, and Smoke, are spoofs of the Predator. They have dreadlocks, masks like the Predator's, and one even has a self destruct Fatality accompanied by an evil laugh. They're also expert hunters, like the Predator.