In Italy, where the show is broadcast with the title "La Tata", Fran's name is Francesca and her origins are not Jewish but Italian (from Frosinone in Ciociaria, to be more precise).
Fran Drescher guest-starred as herself on the penultimate episode, reminding Fran Fine Sheffield and the audience not to miss the series' finale the next week.
Several episodes were shelved after the network decided to have the show cancelled.
When the show was broadcast in the UK, many viewers wrote in to chide Charles Shaughnessy over his "fake" English accent, and suggested he practice with co-star Daniel Davis on how to do a proper English accent. The cast found this quite amusing, as Shaughnessy is a native Englishman born in London, while Davis is an American born in Arkansas.
Fran is short for Francine (also Fran Drescher's real name)
During the show's fifth season run, both Lauren Lane and Rachel Chagall became pregnant twice on the show. But unlike other sitcoms, that hid their pregnant actresses behind props or had them sitting, producers of this show made no attempt to hide or explain the growing bellies, except for one episode were C.C. makes a reference to Elaine on "Seinfeld" (1990) being hidden by props when she became pregnant and she is jokingly hiding herself with props.
"The Nanny" was more of a family affair than most shows since Fran Drescher's company produced the show and hired many friends and relatives to be regulars, guest stars and production staff. The show was also on six years without a major change in casting which was due in part to the congenial working conditions on the set of the show.
To cover Lauren Lane's possible absence during the end of her pregnancy, a storyline was introduced featuring CC taking a trip to an insane asylum.
Brighton's middle name is Milhouse.
Rachel Chagall's twins (born 1999) are named Eve and Jonah; the same names as Fran and Maxwell's twins, Eve Catherine and Jonah Samuel, born on the show.
The set used for the house was the exact same as the one in "Sister, Sister" (1994).
The producers planned to make the main character of Fran an Italian-American, however Drescher wanted the character to remain Jewish. The character of Val Toriello, however, is Italian-American, although Rachel Chagall is actually Jewish.