- The home game scenes were filmed at Milwaukee's County Stadium, which has since been torn down, where Bob Uecker, who portrays announcer Harry Doyle, called games for the Brewers and played for the old Milwaukee Braves. The exterior stadium shots use Cleveland's Municipal Stadium, which has since been torn down.
- Many of the baseball players in the scenes filmed at Hi Corbett Field in Tucson, Arizona were members of the University of Arizona baseball team.
- Just before Rick Vaughn (Charlie Sheen) gives up a home run to Heywood for the second time, Harry Doyle (Bob Uecker) goes over how the other runners got on base. One of the players he mentions is Bill Leff, who actually is the actor who plays Bobby James in the movie.
- In the commercial for the movie when it was in the theaters, there was a scene in which Ricky Vaughn, Jake Taylor, and Willy Hays are in the restaurant, and they are discussing a homerun Ricky gave up to a batter. Jake says to Ricky, "That ball wouldn't have gone out of a lot of parks." Ricky says, "Name one." Jakes pauses and says, "Yellowstone." This scene was omitted from the theatrical release, but was written into the script of Major League II (1994).
- The opponent slugger was played by Peter Vuckovich, a former pitcher.
- Peter Vuckovich, who played Yankees home run threat Haywood, was in real life a pitcher who never hit a single home run in his entire 11 year major league career.
- 'Charlie Sheen' was a high school pitcher who was offered a baseball scholarship to the University of Kansas. In the movie he threw a 101mph fastball, but in reality Sheen could throw in the high 80s. This made it easier to simulate the fastball on film.
- The restaurant where Lynn Wells (Rene Russo) is spotted on a date is in Milwaukee. It was at the time a gourmet restaurant, stood empty for a time and then was a Russian Restaurant and dance club. It again sat empty for a period and is currently (2005) a Baptist Church.
- A scene featuring the wedding of Jake Taylor and Lynn Wells was shot and to occur after the Indians victory over the Yankees in the end but it was deleted because the producers felt that the wedding scene would put the focus of the movie on Jake and Lynn and not the team.
- In the seasonal opener game, a sign on the outfield wall displaying the Milwaukee Brewers classic ball and mitt logo can be clearly seen. Bernie Brewer's house and beer mug was dismantled for the shooting of the movie, as to not give the identity of the interior shots of the stadium.
- In April 2007, due to snow in Cleveland, the real Cleveland Indians were unable to open their home season at Jacobs Field. Miller Park in Milwaukee, which had been built as the replacement for Milwaukee County Stadium in the 1990s and had been constructed with a retractable dome, was chosen to be the 'stand-in' for the Indians' home turf.
- Because of the stadium filmed in the movie and the fact that the Indians played a 'home' series at Milwaukee's new ballpark, the Indians were unofficially dubbed "The Cleveland Indians of Milwaukee." Coincidentally, the team they played was "The Los Angeles Angels of Anaheim."
- In the scene where Jake invades Lynn's party, one of the guests asks how much Jake makes in the Majors. He replies, "I make the league minimum." At the time(1989) the MLB salary minimum was $62,500. Average household income in 1990 is roughly $30,000. So he was making a very respectable double the average household income.
- After Vaughn strikes out Heyward, he is congratulated in the dugout by a player named "Keltner". Ken Keltner was the 3rd baseman on the 1941 Indians who's fielding heroics ended Joe DiMaggio's 56 game hit streak.
- In the final game, Willie Mays Hayes makes a great catch at the wall, in front of a Minnesota Twins banner. Hall-of-Famer Kirby Puckett (of the Twins) was legendary for his gravity-defying catches off the centerfield wall, especially in the 1991 World Series.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: In the film's original ending, Rachel Phelps admits before the final game that her bitchy persona was all an act in order to fire up the players. She says had they not had a good season, the team might have gone bankrupt. Audiences preferred the bitchy Rachel, so the ending was re-shot to show her misery when the Indians won. The alternate ending appears on the Wild Thing Edition DVD.
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