Filming started with Ian McShane as Howard Carter, but just three days into production, he and Eva Marie Saint were injured in an automobile accident during filming of a scene at Luxor, Egypt. The automobile was totaled, but Saint wasn't injured. McShane, however, broke his leg and Robin Ellis was cast in his place at very short notice.
Interior and exterior scenes at the beginning of this movie are clearly shot at Highclere Castle, later to become quite well know for posing as the fictional "Downton Abbey" in the popular TV series (2010-2015) and movie (2019).
Gina Lollobrigida was originally announced for a role.
During production in England, the production company manager was hospitalized for a major operation; a production company executive caught pneumonia and was placed into intensive care; and the production company's publicist's wife was in a car accident and was hospitalized.