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Al Mulock, who played one of the three gunmen in the opening sequence, committed suicide by jumping from his hotel window in full costume after a day's shooting. Production manager Claudio Mancini and screenwriter Mickey Knox, who were sitting in a room in the hotel, witnessed Mulock's body pass by their window. Knox recalled in an interview that while Mancini put Mulock in his car to drive him to the hospital, director Sergio Leone said to Mancini, "Get the costume! We need the costume!" Mulock, who had appeared as the one-armed bounty hunter in Leone's "The Good, The Bad & The Ugly", was wearing the costume he wore in the movie when he made his fatal leap.
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Body count: 29
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Henry Fonda originally turned down a role in the picture. Director Sergio Leone flew to the United States and met with Fonda, who asked why he was wanted for the movie. Sergio replied, "Picture this: the camera shows a gunman from the waist down pulling his gun and shooting a running child. The camera pans up to the gunman's face and... it's Henry Fonda." (Until then, and with one exception, Fonda had only been cast in "good guy" roles. Leone wanted the audience to be shocked.)
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After completing the Dollars trilogy (A Fistful of Dollars, For a Few Dollars More, and The Good, the Bad and the Ugly), Sergio Leone didn't want to do another western and began working on Once Upon a Time in America. However, after the huge success of the Dollars Trilogy in the States in 1967 Leone wanted to produce films in the United States and he began selling the idea for Once Upon a Time in America, but studios wouldn't let him do it until he made another Western for them. After thinking about it, Leone concluded that he should do another trilogy which begins with Once Upon a Time in the West, develops into Duck, You Sucker, and ends with Once Upon a Time in America (1984). "Three historical periods which toughened America."
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The Flagstone set reportedly cost as much as the entire budget for Leone's A Fistful of Dollars.
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The main selling point to producers for the use of the Techniscope process was the savings in camera negative. But, another advantage was being able derive the 2.35:1 aspect ratio while shooting with spherical lenses which avoided the distortion created by anamorphics during certain camera moves and extreme close-ups (such as those used by Sergio Leone). This film, together with The Good, the Bad and the Ugly(also directed by Leone and shot by Tonino Delli Colli) are now considered masterpieces in the use of the Techniscope system.
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Co-writer Bernardo Bertolucci says on the film's DVD that when he first suggested to director Sergio Leone that the film's central character be a woman, Leone was hesitant. Leone first budged on this subject by suggesting the introductory shot of Jill would be from below the train platform so the camera could see under Jill's dress and show she wasn't wearing any undergarments. Claudia Cardinale says she was never told this idea and says she probably wouldn't have agreed to be in the movie if it required this shot (suggesting that Leone, mercifully, gave up on the idea in the writing process).
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Leone originally intended to reunite the three stars of The Good, the Bad and the Ugly (Clint Eastwood, Lee Van Cleef and Eli Wallach) in cameo roles as the three gunmen waiting for Harmonica at the start of the film, but when Eastwood was unavailable the idea was scrapped.
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The sheriff was originally to be portrayed by Robert Ryan.
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For this film Claudia Cardinale and Paolo Stoppa take the longest buggy ride in movie history. It begins in Spain and goes through Monument Valley.
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The Indian woman who flees from the train station in the opening sequence was actually played by a Hawaiian princess, Luukialuana (Luana) Kalaeloa (aka Luana Strode). She was the wife of actor Woody Strode.
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The McBain house was built of solid logs that remained following production of the Orson Welles' movie Chimes at Midnight
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Harmonica's unfortunate brother is played by the production manager Claudio Mancini.
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French actor Robert Hossein, who was a good friend of Leone's, was originally to play Morton, but due to scheduling he was unable to take the part, and Gabriele Ferzetti was cast instead.
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John Landis was one of the stunt men on this film.
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The first draft of the script was 436 pages long.
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The credits, concluding with Director Sergio Leone, last over ten minutes into the start of the film.
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When Henry Fonda was trying to decide whether to be in this film, he asked his friend Eli Wallach, who had just made _Il buono, il brutto, il cattivo. (1966) with Sergio Leone, if he should take the part of Frank. Wallach said that he had to do it and told Fonda, "You will have the time of your life." (Similarly, it was Fonda, saying he considered Leone one of the greatest directors he ever worked with, who persuaded 'James Coburn' to take the part of Mallory in the second "Once Upon a Time..." film, Duck, You Sucker.)
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Henry Fonda prepared for his role as the villain "Frank" by arriving in Italy with a pair of brown colored contact lenses and a grown mustache. When Sergio Leone saw them, he ordered them removed. Leone had planned an important close-up shot of Frank's entrance and wanted the audience to instantly recognize Fonda with those blue eyes.
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Ennio Morricone composed the musical score to the original screenplay by Sergio Leone and Bernardo Bertolucci. The plot was subsequently changed, and in many places, Leone directed the film to the existing musical score.
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The original intent for the opening scene was to use music already composed by composer Ennio Morricone. However, the attempted blend didn't seem to fit well. The decision was made to drop Morricone's score from the opening train station sequence and record the ambient sounds relating to the scenes (including the squeaking windmill and individual footsteps) after Morricone experienced a musical performance created by using only the sounds of a metal ladder. This created an exaggerated version of what had come to be known as "spaghetti sound".
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For the opening sequence where the three dusters waited for the train, filmmakers lightly coated the face of Jack Elam with jam and began filming close-ups while letting a fly out of a jar filled with flies, attempting to get Elam's reaction as one would light on his cheek.
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Sergio Leone made hundreds of references to films that influenced him. Some were quite obvious (like three men waiting for the train as in High Noon) and some were very subtle, like the choice of Woody Strode's sawed-off Winchester rifle, similar to the weapon Steve McQueen carried in the TV series Wanted: Dead or Alive. McQueen referred to this unique weapon as a "Mare's Leg".
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The final duel between Frank and Harmonica is shot almost exactly like the one in Robert Aldrich's The Last Sunset between Rock Hudson and Kirk Douglas, a film that Bernardo Bertolucci was a huge fan of.
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Although Lionel Stander's establishment is located in Monument Valley, the interiors were actually shot at Cinecitta. Cheyenne's men enter with a cloud of red dust. The red dust was actually dust imported from the Monument Valley location.
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This marked the first of the last three films to be fully directed by Sergio Leone. All three of his last films would be edited for U.S. distribution resulting in box office failure in the U.S. although the uncut international versions would be successful in other countries.
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The character name of "Brett McBain" was derived from two famous U.S. mystery writers, Brett Halliday and Ed McBain (Evan Hunter).
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Jason Robards showed up at the set completely drunk on the first day of filming, and Leone threatened to fire him if he ever did that again. Robards was generally well-behaved thereafter, though in June 1968, after receiving word of the assassination of Robert F. Kennedy, Robards broke down and refused to perform until the day was over, and Leone decided to stop filming for the day.
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Sergio Leone originally offered the role of Harmonica to Clint Eastwood, but he turned it down, so Leone hired Charles Bronson instead. James Coburn was also approached for the role Harmonica, but Coburn demanded too much money.
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Robert Ryan was offered the role of the Sheriff played by Keenan Wynn. Ryan initially accepted but backed out after being given a larger role in Sam Peckinpah's The Wild Bunch.
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Over half of the film's budget went to paying the actors' salaries.
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"The producers are grateful to the Navajo Tribal Council for their hospitality in their territories in Arizona and Utah."
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In the opening scene, when Stony (Woody Strode) is under the water tank, water kept dripping onto the brim of his hat, causing him to flinch and Sergio Leone to stop filming. Leone was going to move Strode but, at the actor's suggestion, kept him in the same spot. Strode wanted his character to be viewed as so cool as to not let dripping water affect him. On the spur of the moment, Leone had Strode take off his hat and drink the collected water.
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The original script called for Clint Eastwood, Lee Van Cleef and Eli Wallach (in their roles from The Man With No Name trilogy) to be the trio gunned down at the train station. Eastwood, whose star was rising in Hollywood, did not want to be seen as a villain and objected. When he did, Wallach backed out as well. Leone had to pull Jack Elam and Strode from later in the script. Though they got paid handsomely, they lost almost 30 minutes of screen time. In the original script, they would have killed Harmonica to fulfill Jason Robards' prediction that those who live by the sword die by it as well. With Elam and Strode changed, Harmonica was allowed to survive.
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Director Trademark 

Sergio Leone:  [close-up]  in most gun-fight scenes.
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Sergio Leone:  [theme]  Jill, Harmonica, Frank, and Cheyenne.
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