A day before his death, it had been announced that Moonbin was set to perform at the Dream Concert in Busan with fellow Astro member Sanha as part of their duo, Moonbin & Sanha.
Moonbin debuted as part of the six-member boy group Astro on February 23, 2016. Their debut extended play, Spring Up, contained five songs, including the lead single "Hide & Seek".
In 2018, Moonbin joined the cast of The Ultimate Watchlist of Latest Trends, participating in the first two seasons. The following year, he was cast in Moments of Eighteen, where he played the character of Jung Oh-je.
In 2009, he had his first acting role in the Korean drama Boys over Flowers where he played the younger version of Kim Bum's character.