- Was an infielder with the Boston Red Sox (2004-2012[start]), Chicago White Sox (2012[end]), and New York Yankees (2013).
- Became just the 7th player in Boston's club history to hit a homer in his first major league game
- Inducted into the Portland Sea Dogs Hall of Fame in 2013.
- 2-time All-American at the University of Cincinnati. Member of the Sycamore High School 1994 AAU National Championship squad.
- In 2004, named the club's Rookie of the Year by the Boston chapter of the Baseball Writers' Association of America.
- Played third base in his first two seasons in Boston because he would be temporarily called up, but currently plays first base full season.
- Made major league debut on 15 May 2004. Played in final major league game 13 June 2013.
- Had a wedding ceremony with ex-girlfriend Enza Sambataro in Cabo San Lucas, Mexico on November 9, 2008. However they never filed the paperwork needed to make the marriage official and split up shortly after.
- Brother-in-law of New England Patriots QB Tom Brady and Gisele Bündchen.
- Inducted into the University of Cincinnati's James P. Kelly Athletics Hall of Fame in 2007.
- The University of Cincinnati baseball program retired his jersey number, 36, on 16 May 2015.
- Inducted into the International Jewish Sports Hall of Fame in 2019.
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