- Often wrote manga which featured a giant robot that obeyed the commands of its human controller such as "Tetsujin nijuhachi-go" ("Gigantor"), "Jaianto robo" ("Johnny Sokko and His Flying Robot"), and "Babel nisei" ("Babel II").
- He entered the Sumitomo Mitsui Banking Corporation after graduation from high school, but quit his job before five months had passed because there was no time to draw a manga. He found a new job as a publicity department member for a film company based in Kobe and pursued his manga artist career there on his free time.
- Osamu Tezuka's "Metropolis" manga made a deep impression on Yokoyama, who wished to become a manga artist in earnest, so he contributed his works to a comic book back in his high school days.
- Yokoyama established the formats of various genres of current Japanese manga and anime. Whereas many manga artists preferred their original stories not to be changed when adapted, Yokoyama was realistic and tolerant, so many of his manga were easily made into anime/tokusatsu adaptations.
- Yokoyama died on April 15, 2004 from severe burns over most of his body that were received during a fire at his home in Tokyo. He was found unconscious in bed and died 16 hours later at a nearby hospital. Police found an ashtray by Yokoyama's bedside and suspected that the fire was caused by a lit cigarette. He was already in such a state of health that he was not able to move freely, which likely contributed to his death.
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