- Susan and Kevin Nealon were married in Lake Como, Italy, with 4 people in attendance. Photographers crashed their wedding ceremony, thinking that Matt Damon was the groom.
- Susan and her husband, Kevin Nealon, became the parents of a boy, Gable Nealon, on January 29, 2007 at St. John's Health Center in Santa Monica.
- Co-founder of the Leaky Pen writing contest which provides financial support to comedic high school seniors.
- Can recite the 50 states, in alphabetical order, in less than a minute.
- Susan's mother is a top fertility specialist, practicing in Nashville, TN.
- She is a documented descendant of Mayflower pilgrims through her mother's lineage.
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