- Son of Dick Van Dyke (who is also his acting mentor). Stepson of Arlene Silver. Nephew of actor Jerry Van Dyke. Brother of Stacy Van Dyke, Carrie Beth Van Dyke and Christian Van Dyke.
- He and his father, Dick Van Dyke, returned to television in the Hallmark Channel movie, Murder 101 (2006). (January 2006)
- Has four children: Carey Van Dyke, Shane Van Dyke, Wes Van Dyke and Taryn Van Dyke. Shane Van Dyke (who also had a small running role as medical student "Alex Smith" on Diagnosis Murder (1993)), and Carey Van Dyke guest-starred in two episodes of Diagnosis Murder (1993) written by their father. Barry and Carey Van Dyke wrote the very last episode of Diagnosis Murder (1993) (in the 8th season), called The Blair Nurse Project (2001).
- Best known by the public for his role as Det. Steve Sloan on Diagnosis Murder (1993).
- Became a grandfather in 2001 when his oldest son, Carey Van Dyke, and his wife, Anne, had a baby girl on July 26, 2001. The baby's name is Ava.
- Filming with his sons (Shane Van Dyke and Carey Van Dyke), and father (Dick Van Dyke) New Age (2008) for the Hallmark Channel. (November 2007)
- Attended Pierce Junior College in LA - majored in Theater Arts.
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