- Barbra Streisand bought the film rights to Kramer's play, "The Normal Heart", in 1985. However, Kramer withdrew them in 1995, after Streisand had not made the film in 10 years. Streisand had planned to direct the film after The Mirror Has Two Faces (1996), but that production was so problematic that she could not face directing again so soon. Kramer claimed Streisand preferred to do other work, instead, thereby blocking other directors from making the film. His memorable comment on Streisand's hesitance was "P*ss or get off the pot!".
- In July 2013, Kramer's marriage, at age 78, to architect David Webster, 66, took place in a New York City hospital where Kramer was recovering from surgery.
- Founded ACT UP in 1987, an AIDS advocacy and protest group.
- His play, "The Normal Heart", performed at the Next Theatre Company in Chicago, Illinois, was awarded the 1987 Joseph Jefferson Award for Play Production.
- Nominated for the 1993 Pulitzer Prize for Drama for the play "The Destiny of Me".
- Screenwriter and Pulitzer Prize-winning playwright Tony Kushner described his off/on-again friend Larry Kramer as "relentless but not revolutionary [but wielding] a rage that formed the words that helped fuel a revolution. He was sometimes a misery and often an unmatchable mensch. He was a blisteringly magnificent solar flare of a human being. And I'll miss him forever".
- Donated his papers to Yale.
- Threw a drink in the face of closeted Conservative activist Terry Dolan when he encountered him at a Washington party.
- Biography/bibliography in: "Contemporary Authors". New Revision Series, Vol. 132, pp. 217-222. Farmington Hills, MI: Thomson Gale, 2005.
- His play, "The Normal Heart" at the TimeLine Theatre Company in Chicago, Illinois was awarded the 2014 Joseph Jefferson Equity Award for Midsize Play Production.
- Son of Rea (Wishengrad), a teacher and shoe store employee, and George Kramer, an attorney. His father was born in Connecticut, to Russian Jewish parents. His mother was a Russian Jewish immigrant.
- American writer and intellectual hero Susan Sontag called Kramer "one of America's most valuable troublemakers".
- At his death he was working on a new play, "An Army Of Lovers Must Not Die".
- Yale University awarded him an honorary degree in 2015.
- In 2014 he received a special Tony Award from the American Theatre Wing for his humanitarian work.
- Served in the United States Army after graduating from Yale.
- Began his career working for Columbia Pictures in New York, where he was involved in the productions of Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb (1964) and Lawrence of Arabia (1962).
- Graduated from Yale University in 1957.
- Between 2015 and 2020 he published Volumes I & II of his nearly 1,700 page book "The American People".
- In 1988, Kramer learned that he was HIV-positive.
- Writer Calvin Trillin was a classmate at Yale and longtime friend.
- Compared Dr. Anthony Fauci, Director of the National Institute of Allergy & Infectious Diseases, to Adolf Eichmann.
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