- She is of Cuban descent.
- Announced both of her pregnancies - in 2015 and 2019 - on the same day which is November 16th.
- Mother, with husband David Fumero, of sons Enzo Fumero (b. March 24, 2016), and Axel Fumero (b. February 14, 2020).
- Married her co-star David Fumero who plays her cousin on One Life to Live (1968).
- Has been a dancer since childhood.
- Graduated from NYU with a BA in Drama.
- When she was hired to play Adriana on One Life to Live (1968), the original intention of the storyline was for Dorian Lord to pretend that Adriana was her daughter to gain her inheritance. When producers saw the striking resemblance between Melissa Gallo and Robin Strasser they decided to make the family ties permanent and the shocking twist of the storyline was the Adriana really was Dorian's daughter. This created some storyline problems because the character had been paired romantically with Dorian's grandson River Carpenter.
- Her husband was in the United States Marine Corps.
- Shares her One Life to Live (1968) dressing room with Kathy Brier.
- In One Life to Live (1968), Melissa Fumero is punched twice by Farah Fath.
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