After being dumped by Leslie, Howard heads to Las Vegas with Leonard and Raj. Meanwhile, Penny is forced to take in Sheldon after he locks himself out of his apartment.
Kripke expresses interest in Amy while leading a fencing lesson for the guys. Meanwhile, Stuart seeks help from the girls in getting more women interested in the comic book store.
Sheldon is thrilled when his Meemaw comes to visit, but his excitement quickly fades when she butts heads with Amy. Meanwhile, Raj meets a girl at the comic book store who makes him question his relationship with Emily.