Dr Henry Frankenstein is obsessed with assembling a living being from parts of several exhumed corpses.
The only entry on this list I can appreciate for its filmic value. It's not a bad film by any stretch.
However, the novel is beautiful, and Karloff's Frankenstein has turned into a watered down pop-culture icon. Which isn't necessarily the film's fault, but the appearance and temperament of the monster are so unlike that of the character found in the novel that any current 'remake' or 'readaptation' becomes merely a remake of the film that got it wrong in the first place. Igor wasn't in the book, Dr. Frankenstein isn't the mad, deranged type, the Monster isn't a lumbering, misunderstood man-child, the film is missing the arctic landscapes and pivotal scenes found in the story... I can go on and on, and obviously hoping for a completely faithful film is a bit naive, but for such an influential piece of classic literature, I find that a film that does it justice is overdue.
As far as directing choices, I have no clue at this point. Guillermo Del Toro once optioned a promised version, but has instead opted for the more over-the-top action films as of late.