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- In 1985 Dallas, electrician and hustler Ron Woodroof works around the system to help AIDS patients get the medication they need after he is diagnosed with the disease.
- Gregory invites seven friends to spend the summer at his large, secluded 19th-century home in upstate New York. The seven are: Bobby, Gregory's "significant other," who is blind but who loves to explore the home's garden using his sense of touch; Art and Perry, two "yuppies" who drive a Volvo and who celebrate their 14th anniversary together that summer; John, a dour expatriate Briton who loathes his twin brother James; Ramon, John's "companion," who is physically attracted to Bobby and immediately tries to seduce the blind man; James, a cheerful soul who is in the advanced stages of AIDS; and Buzz, a fan of traditional Broadway musicals who is dealing with his own HIV-positive status.
- A telephone call takes Jack back to the last time he was with his ex-girlfriend, Tina Cassidy, as she approached the final stages of her painful battle against AIDS.